comparison of immune regulatory factors in acute and chronic lesions of cutaneous leishmaniasis due to leishmania major
نویسندگان
چکیده
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منابع مشابه
Comparison of immune regulatory factors in acute and chronic lesions of cutaneous leishmaniasis due to Leishmania major
BACKGROUND Adaptive immune response is an important factor in the healing process and development of protection in cutaneous leishmaniasis (CL). Little information is available in human CL about the importance of the balance between effector and regulatory immune responses. Therefore, the aim of this study was to asses messenger ribonucleic acid (mRNA) expression of interleukin-10 (IL-10), IL-4...
متن کاملRegulatory T-cell profile in early and late lesions of cutaneous leishmaniasis due to Leishmania major
CONTEXT Cutaneous leishmaniasis (CL) is a public health problem in several endemic countries. Recent studies on mouse model and also a few clinical experiments showed that the type of immune response generated at the site of infection and especially balance between regulatory and effector T-cells determines the outcome of the disease toward self-limiting or long-lasting lesions. AIMS The aim ...
متن کاملEVALUATION OF CELLULAR IMMUNE RESPONSES TO AMASTIGOTE SOLUBLE Leishmania major ANTIGENS IN RECOV ERED CASES OF CUTANEOUS LEISHMANIASIS
This study was performed in order to define the cellular immune response of 12 recovered cutaneous leishmaniasis subjects to different soluble antigens of the amastigote form of Leishmania major. A soluble leishmanial antigen preparation (SLA) derived from highly-purified amastigotes from infected nude mice was fractionated by Mono Q column using Fast Protein Liquid Chromatography (FPLC) s...
متن کاملIntralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis.
The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL). We demonstrated that Treg cells preferentially accumulate in lesions from ACL patients during the early phase of infection (lesion duration of less than 1 month). In addition, levels of Foxp...
متن کاملfaculty of psychology and social sciences group of anthropology master thesis in major of anthropology
چکیده پایان نامه (شامل خلاصه، اهداف، روش های اجرا و نتایج به دست آمده): کار جمع آوری گو یش های محلی در سال های اخیر شتاب امیدوار کننده ای به خود گرفته است. شاید از بارزترین اهداف جمع آوری گویش های مختلف، ثبت و ضبط آن، جلوگیری از نابودی و مهمتر از همه حل مشکلات دستوری زبان رسمی باشد. دقت در فرآیند های زبانی گویش های محلی نوع ارتباط مردم نواحی مختلف با پیرامون نشان را به ما نشان خواهد داد. از س...
The Histopathological Changes and Immunohistochemical Findings of Acute, Chronic Nonlupoid and Chronic Lupoid Types of Cutaneous Leishmaniasis
Background & Aims: Dry type localized cutaneous Leishmaniasis due to Leishmania tropica is one of the most prevalent cutaneous parasitic infections in Kerman province. It seems that cellular immune response and the nature of immune inflammatory cells comprising the inflammatory background play a determinant role in this infection. Methods: Skin biopsies of 53 patients with acute(<2 years durati...
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عنوان ژورنال:
journal of research in medical sciencesجلد ۱۹، شماره ۳، صفحات ۰-۰
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